Results for 'David A. Long'

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  1.  27
    Selecting a subjective health status measure for optimum utility in everyday orthopaedic practice.David A. McQueen, Michael J. Long & John R. Schurman - 2005 - Journal of Evaluation in Clinical Practice 11 (1):45-51.
  2.  18
    Kant's Pragmatic Horizon.David A. Long - 1982 - American Philosophical Quarterly 19 (4):299 - 313.
  3.  34
    Capturing the full measure of patient outcome improvement using a self‐assessed health adjustment.Michael J. Long, David A. McQueen, Mary Lescoe-Long & John R. Schurman - 2005 - Journal of Evaluation in Clinical Practice 11 (5):484-488.
  4.  30
    A little mechanism can go a long way.David A. Schwartz, Mark Weaver & Stephen Kaplan - 1999 - Behavioral and Brain Sciences 22 (4):631-632.
    We propose a way in which Barsalou could strengthen his position and at the same time make a considerable dent in the category/abstraction problem (that he suggests remains unsolved). There exists a class of connectionist models that solves this problem parsimoniously and provides a mechanistic underpinning for the promising high-level architecture he proposes.
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  5.  50
    The Moral Status of Nuclear Deterrent Threats*: DAVID A. HOEKEMA.David A. Hoekema - 1985 - Social Philosophy and Policy 3 (1):93-117.
    Ethical reflection on the practice of war stands in a long tradition in Western philosophy and theology, a tradition which begins with the writings of Plato and Augustine and encompasses accounts of justified warfare offered by writers from the Medieval period to the present. Ethical reflection on nuclear war is of necessity a more recent theme. The past few years have seen an enormous increase in popular as well as scholarly concern with nuclear issues, and philosophers have joined theologians (...)
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  6.  12
    The collective classic: a case for the reading of science.David E. Goodney & Carol S. Long - 2003 - Science & Education 12 (2):167-184.
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  7.  12
    Technology and the Modern World-System: Some Reflections.David A. Smith - 1993 - Science, Technology and Human Values 18 (2):186-195.
    This article represents a preliminary attempt to conceptualize the relationship between technology and global inequality, using a political economy of the world-system perspective. Despite the crucial role that technical innovation and adaptation play in the process of international development, many macroanalyses of social change focus little explicit attention on technology. Only neoevolutionary theory discusses its role in long-term social change, and then in ways that miss some key dimensions. The author argues that technology is a social product designed to (...)
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  8. Somaesthetics and Racism: Toward an Embodied Pedagogy of Difference.David A. Granger - 2010 - Journal of Aesthetic Education 44 (3):69.
    In lieu of an abstract, here is a brief excerpt of the content:Somaesthetics and Racism:Toward an Embodied Pedagogy of DifferenceDavid A. Granger (bio)IntroductionThe philosopher Ludwig Wittgenstein once remarked that "The human body is the best picture of the human soul."1 There is a basic truth in this assertion that we recognize (I want to say) intuitively: the notion that human beings are parts both mental and physical, that these facets are ultimately interdependent, and that they are in some measure correlated (...)
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  9.  19
    The Medicalization of Poverty: A Dose of Theory.David A. Hyman - 2018 - Journal of Law, Medicine and Ethics 46 (3):582-587.
    Is the medicalization of poverty a rational and humane response to an intractable problem, or just the latest in a long series of ineffective and costly attempts to address the problem? Considerable ink has been spilled on the dispute, with each side marshalling heart-rending anecdotes to help make their case — along with the obligatory statistics and regression analyses. Rather than add more verbiage to that dispute, this article sketches out a framework for understanding the phenomenon of medicalization, along (...)
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  10.  50
    Rushing to revolution? A second look at globalization and justice.David A. Reidy - 2006 - Economics and Philosophy 22 (1):125-137.
    In Globalization and Justice, Kai Nielsen brings his distinctive and passionate voice and considerable philosophical abilities to one of the pressing issues of our time: Is justice possible in our increasingly globalized world? Nielsen argues that it is, though the demands of justice are great, the challenges substantial, and the odds very long. Without a clear philosophical understanding of justice and a firm and focused political will, Nielsen maintains, we are likely to have globalization without justice. This is surely (...)
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  11.  30
    Teaching and Assessing Learning About Virtue: Insights and Challenges From a Redesigned Journalism Ethics Class.David A. Craig & Mohammad Yousuf - 2018 - Journal of Media Ethics 33 (4):181-197.
    ABSTRACTVirtue ethics, a topic of growing interest in media ethics and philosophy more broadly, poses challenges for classroom instruction because it is rooted in long-term development of character. This article explores approaches for incorporating virtue into media ethics instruction and assessing associated student learning, based on an analysis of how students in a journalism ethics class demonstrated their understanding and application of virtues through activities tailored to virtue ethics. The analysis, in addition to suggesting the value of assignments such (...)
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  12.  16
    The Ultimate Tool: The Body, Planning of Physical Actions, and the Role of Mental Imagery in Choosing Motor Acts.David A. Rosenbaum - 2021 - Topics in Cognitive Science 13 (4):777-799.
    The ultimate tool, it could be said, is the brain and body. Therefore, a way to understand tool use is to study the brain's control of the body. A more manageable aim is to use the tools of cognitive science to explore the planning of physical actions. Here, I focus on two kinds of physical acts which directly or indirectly involve tool use: producing finger‐press sequences, and walking and reaching for objects. The main question is how people make choices between (...)
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  13.  39
    Class, consciousness, and the fall of the bourgeois revolution.David A. Bell - 2004 - Critical Review: A Journal of Politics and Society 16 (2-3):323-351.
    Abstract The Marxian vulgate, which long dominated the historiography of the French Revolution, and which was broadly accepted in the social sciences, is no longer sustainable. But newer attempts to frame the issue of class in entirely linguistic terms, producing the claim that France had no bourgeoisie because few people explicitly described themselves as ?bourgeois,? are not entirely convincing. The Revolution brought into being, and helped to sustain, a new social group: the ?state bourgeoisie,? which defined itself by its (...)
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  14.  15
    Are secondary effects of bisphosphonates on the vascular system of bone contributing to increased risk for atypical femoral fractures in osteoporosis?David A. Hart - 2023 - Bioessays 45 (4):2200206.
    Osteoporosis (OP) is a bone disease which affects a number of post‐menopausal females and puts many at risk for fractures. A large number of patients are taking bisphosphonates (BPs) to treat their OP and a rare complication is the development of atypical femoral fractures (AFF). No real explanations for the mechanisms underlying the basis for development of where AFF develop while on BPs has emerged. The present hypothesis will discuss the possibility that part of the risk for an AFF is (...)
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  15.  96
    Can Health Care Rationing Ever Be Rational?David A. Gruenewald - 2012 - Journal of Law, Medicine and Ethics 40 (1):17-25.
    Mr. M. was a 77-year-old decisionally incapacitated long-term nursing home resident with chronic schizophrenia who was admitted to the hospital with a bacterial pneumonia. His past medical history was notable for deteriorating functional status over the past 2-3 years, urinary retention requiring chronic indwelling bladder catheterization, and two recent hospitalizations for urinary tract infections leading to sepsis. He developed respiratory failure soon after admission and was intubated and placed on mechanical ventilation. Follow-up studies suggested worsening pneumonia and acute respiratory (...)
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  16.  14
    Government and Markets: Toward a New Theory of Regulation.Edward J. Balleisen & David A. Moss (eds.) - 2009 - Cambridge University Press.
    After two generations of emphasis on governmental inefficiency and the need for deregulation, we now see growing interest in the possibility of constructive governance, alongside public calls for new, smarter regulation. Yet there is a real danger that regulatory reforms will be rooted in outdated ideas. As the financial crisis has shown, neither traditional market failure models nor public choice theory, by themselves, sufficiently inform or explain our current regulatory challenges. Regulatory studies, long neglected in an atmosphere focused on (...)
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  17.  60
    Role of details in the long-term recognition of pictures and verbal descriptions.Thomas O. Nelson, Jacqueline Metzler & David A. Reed - 1974 - Journal of Experimental Psychology 102 (1):184.
  18.  17
    Further investigation of viewing conditions on standard pseudoisochromatic tests.Gerald M. Long, Brian J. Lyman, Edward P. Monaghan, David L. Penn, Hope A. Brochin & Edgar B. Morano - 1984 - Bulletin of the Psychonomic Society 22 (6):525-528.
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  19.  33
    Art Restoration and Its Contextualization.David A. Scott - 2017 - Journal of Aesthetic Education 51 (2):82-104.
    Art restoration has been around as long as human beings have been involved with artifacts and works of art. Pliny mentions the Shrine of Ceres in the Circus Maximus at Rome.1 When the shrine was undergoing restoration, the embossed work of the walls was cut out and enclosed in framed panels, and figures were taken from the pediment and dispersed. Alteration, or the lack of it, clearly impacts the aesthetic appreciation of works of art, and the hermeneutics of that (...)
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  20.  31
    Relative effects of acoustic and semantic relatedness on clustering in free recall.David Long & Gordon A. Allen - 1973 - Bulletin of the Psychonomic Society 1 (5):316-318.
  21.  21
    Visualizing Tree Structures in Genetic Programming.Jason M. Daida, Adam M. Hilss, David J. Ward & Stephen L. Long - 2005 - Genetic Programming and Evolvable Machines 6.
    This paper presents methods to visualize the structure of trees that occur in genetic programming. These methods allow for the inspection of structure of entire trees even though several thousands of nodes may be involved. The methods also scale to allow for the inspection of structure for entire populations and for complete trials even though millions of nodes may be involved. Examples are given that demonstrate how this new way of “seeing” can afford a potentially rich way of understanding dynamics (...)
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  22.  89
    Remote home health care technologies: how to ensure privacy? Build it in: Privacy by Design.Ann Cavoukian, Angus Fisher, Scott Killen & David A. Hoffman - 2010 - Identity in the Information Society 3 (2):363-378.
    Current advances in connectivity, sensor technology, computing power and the development of complex algorithms for processing health-related data are paving the way for the delivery of innovative long-term health care services in the future. Such technological developments will, in particular, assist the elderly and infirm to live independently, at home, for much longer periods. The home is, in fact, becoming a locus for health care innovation that may in the future compete with the hospital. However, along with these advances (...)
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  23.  21
    The Bioethics of Built Space: Health Care Architecture as a Medical Intervention.Diana C. Anderson, Stowe Locke Teti, William J. Hercules & David A. Deemer - 2022 - Hastings Center Report 52 (2):32-40.
    Hastings Center Report, Volume 52, Issue 2, Page 32-40, March‐April 2022.
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  24. Plato: Meno and Phaedo.David Sedley & Alex Long (eds.) - 1980 - Cambridge University Press.
    Plato's Meno and Phaedo are two of the most important works of ancient western philosophy and continue to be studied around the world. The Meno is a seminal work of epistemology. The Phaedo is a key source for Platonic metaphysics and for Plato's conception of the human soul. Together they illustrate the birth of Platonic philosophy from Plato's reflections on Socrates' life and doctrines. This edition offers new and accessible translations of both works, together with a thorough introduction that explains (...)
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  25.  10
    Evolution and religion in American eduation: an ethnography.David E. Long - 2011 - Dordrecht: Springer.
    Evolution and Religion in American Education shines a light into one of America’s dark educational corners, exposing the regressive pedagogy that can invade science classrooms when school boards and state overseers take their eyes off the ball. It sets out to examine the development of college students’ attitudes towards biological evolution through their lives. The fascinating insights provided by interviewing students about their world views adds up to a compelling case for additional scrutiny of the way young people’s educational experiences (...)
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  26.  50
    Causality influences children's and adults' experience of temporal order.Emma C. Tecwyn, Christos Bechlivanidis, David A. Lagnado, Christoph Hoerl, Sara Lorimer, Emma Blakey, Teresa McCormack & Marc J. Buehner - 2020 - Developmental Psychology 56 (4):739-755.
    Although it has long been known that time is a cue to causation, recent work with adults has demonstrated that causality can also influence the experience of time. In causal reordering (Bechlivanidis & Lagnado, 2013, 2016) adults tend to report the causally consistent order of events, rather than the correct temporal order. However, the effect has yet to be demonstrated in children. Across four pre-registered experiments, 4- to 10-year-old children (N=813) and adults (N=178) watched a 3-object Michotte-style ‘pseudocollision’. While (...)
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  27.  77
    Different Vocal Parameters Predict Perceptions of Dominance and Attractiveness.Carolyn R. Hodges-Simeon, Steven J. C. Gaulin & David A. Puts - 2010 - Human Nature 21 (4):406-427.
    Low mean fundamental frequency (F 0) in men’s voices has been found to positively influence perceptions of dominance by men and attractiveness by women using standardized speech. Using natural speech obtained during an ecologically valid social interaction, we examined relationships between multiple vocal parameters and dominance and attractiveness judgments. Male voices from an unscripted dating game were judged by men for physical and social dominance and by women in fertile and non-fertile menstrual cycle phases for desirability in short-term and (...)-term relationships. Five vocal parameters were analyzed: mean F 0 (an acoustic correlate of vocal fold size), F 0 variation, intensity (loudness), utterance duration, and formant dispersion (D f , an acoustic correlate of vocal tract length). Parallel but separate ratings of speech transcripts served as controls for content. Multiple regression analyses were used to examine the independent contributions of each of the predictors. Physical dominance was predicted by low F 0 variation and physically dominant word content. Social dominance was predicted only by socially dominant word content. Ratings of attractiveness by women were predicted by low mean F 0, low D f , high intensity, and attractive word content across cycle phase and mating context. Low D f was perceived as attractive by fertile-phase women only. We hypothesize that competitors and potential mates may attend more strongly to different components of men’s voices because of the different types of information these vocal parameters provide. (shrink)
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  28.  8
    Tacticality, Authenticity, or Both? The Ethical Paradox of Actor Ingratiation and Target Trust Reactions.David M. Long - 2019 - Journal of Business Ethics 168 (4):847-860.
    Ingratiation is an impression management strategy whereby actors try to curry favor with targets, and is one of the more pervasive social activities in a workplace. An assumption in the literature is that a target’s awareness of the tactical purposes behind ingratiation is an ethical concern which triggers suspicions of ulterior motives and casts the actor as distrustful. However, this assumption fails to consider alternative explanations in that ingratiation may also be perceived as occurring for authentic purposes. This alternative view (...)
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  29.  17
    Philosophical Sketches.David W. Long - 2012 - Journal of Indian Philosophy and Religion 17:142-158.
    This cross-disciplinary, cross-cultural paper explores and critiques scientific, philosophical, and psychological concepts of consciousness. It embodies many of the ideas I presented at the First International Conference for the Study of Consciousness Within Science in 1990, a gathering of physicists, neuroscientists, psychologists, and philosophers, all of whom were trying to come to grips with both the experience and the idea of consciousness in their work.
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  30.  39
    Book Review Section 2. [REVIEW]John L. Puckett, Delbert H. Long, Mara Sapon-Shevin, Barbara K. Townsend, Thomas A. Callister Jr, Lois Weis, John H. Scahill, David E. Washburn & Terence O'connor - 1989 - Educational Studies 20 (1):59-106.
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  31.  47
    Motor Control and Sensory Feedback Enhance Prosthesis Embodiment and Reduce Phantom Pain After Long-Term Hand Amputation.David M. Page, Jacob A. George, David T. Kluger, Christopher Duncan, Suzanne Wendelken, Tyler Davis, Douglas T. Hutchinson & Gregory A. Clark - 2018 - Frontiers in Human Neuroscience 12.
  32.  74
    John Henry Newman, Infallibility, and the Development of Christian Doctrine.David P. Long - 2015 - Heythrop Journal 58 (2):181-194.
    This essay charts the parallel growth of Newman's theory of doctrinal development, and infallibility within that doctrinal development, with its author's movement from a via media in Anglicanism to recognition of the truth in the Roman Church. This essay analyzes the theological need for a theory of doctrinal development, the failure of Newman's via media project, and his role as a creative theologian. Then this essay examines in detailed Newman's 1845 Essay on the Development of Christian Doctrine, looking specifically at (...)
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  33.  52
    Rosalind Krauss, David Carrier, and Philosophical Art CriticismRosalind Krauss and American Philosophical Art Criticism: From Formalism to beyond Postmodernism.Daniel A. Siedell & David Carrier - 2004 - Journal of Aesthetic Education 38 (2):95.
    In lieu of an abstract, here is a brief excerpt of the content:The Journal of Aesthetic Education 38.2 (2004) 80-87 [Access article in PDF] The Beauty of Henri Matisse David Carrier Because beauty has for a long time now been politically incorrect (at least among certain influential critics and academic historians) the art of Henri Matisse has recently suffered from a kind of benign neglect. His goals were luxury, calm, and voluptuousness, not social critique. He painted female nudes, (...)
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  34.  62
    Transposable elements and an epigenetic basis for punctuated equilibria.David W. Zeh, Jeanne A. Zeh & Yoichi Ishida - 2009 - Bioessays 31 (7):715-726.
    Evolution is frequently concentrated in bursts of rapid morphological change and speciation followed by long‐term stasis. We propose that this pattern of punctuated equilibria results from an evolutionary tug‐of‐war between host genomes and transposable elements (TEs) mediated through the epigenome. According to this hypothesis, epigenetic regulatory mechanisms (RNA interference, DNA methylation and histone modifications) maintain stasis by suppressing TE mobilization. However, physiological stress, induced by climate change or invasion of new habitats, disrupts epigenetic regulation and unleashes TEs. With their (...)
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  35.  36
    Healthcare students support opt-out organ donation for practical and moral reasons.Long Qian, Miah T. Li, Kristen L. King, Syed Ali Husain, David J. Cohen & Sumit Mohan - 2022 - Journal of Medical Ethics 48 (8):522-529.
    Background and purpose Changes to deceased organ donation policy in the USA, including opt-out and priority systems, have been proposed to increase registration and donation rates. To study attitudes towards such policies, we surveyed healthcare students to assess support for opt-out and priority systems and reasons for support or opposition. Methods We investigated associations with supporting opt-out, including organ donation knowledge, altruism, trust in the healthcare system, prioritising autonomy and participants’ evaluation of the moral severity of incorrectly assuming consent in (...)
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  36.  31
    The Hajj Today. A Survey of the Contemporary Pilgrimage to Makkah.William R. Roff & David E. Long - 1981 - Journal of the American Oriental Society 101 (2):221.
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  37.  29
    Book Review Section 2. [REVIEW]Richard Olmsted, Paula A. Cordeiro, Robert W. Johns, C. David Lisman, Bettye Macphail-Wilcox, Margaret Gillett, Ruth Hayhoe, Delbert H. Long, Joseph S. Malikail & Geoffrey E. Mills - 1991 - Educational Studies 22 (1):65-109.
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  38.  6
    Longing: Jewish meditations on a hidden God.Justin David - 2018 - Eugene, Oregon: Cascade Books.
    Longing is a universal human experience, born of the inevitable gulf between dream and reality, what we need and what we have. While the experience of longing may arise from loss or the awareness of a void in one’s life, it may also become a powerful engine of spiritual growth, prompting one to draw closer to the hidden yet present “Other.” Across the range of Jewish teachings, longing takes center stage in one’s spiritual life. From the Bible through current frontiers (...)
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  39.  55
    Epicurean Psychology and Theology - David Konstan: Some Aspects of Epicurean Psychology. (Philosophia Antiqua, 25.) Pp. x + 83. Leiden: Brill, 1973. Paper, fl. 28. - Dietrich Lemke: Die Theologie Epikurs. Versuch einer Rekonstruktion. (Zetemata, 57.) Pp. 118. Munich: C.H. Beck, 1973. Paper, DM.25.50. [REVIEW]A. A. Long - 1976 - The Classical Review 26 (2):215-217.
  40.  10
    Thinkers of The Twenty Years' Crisis: Inter-war Idealism Reassessed.David Long, Peter Wilson & Peter Colin Wilson - 1995 - Oxford University Press.
    This book reassesses the contribution to international thought of some of the most important thinkers of the inter-war period. It takes as its starting point E.H. Carr's famous critique which, more than any other work, established the reputation of the period as the "utopian" or "idealist" phase of international relations theorizing. This characterization of inter-war thought is scrutinized through ten detailed studies of such writers as Norman Angell, J.A. Hobson, J.M. Keynes, David Mitrany, and Alfred Zimmern. The studies demonstrate (...)
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  41.  33
    Nature, Truth, and Value: Exploring the Thinking of Frederick Ferrz.George Allan, Merle Allshouse, Harley Chapman, John B. Cobb, John Compton, Donald A. Crosby, Paul T. Durbin, Barbara Meister Ferré, Frederick Ferré, Frank B. Golley, Joseph Grange, John Granrose, David Ray Griffin, David Keller, Eugene Thomas Long, Elisabethe Segars McRae, Leslie A. Muray, William L. Power, James F. Salmon, Hans Julius Schneider, Kristin Shrader-Frechette, Udo E. Simonis, Donald Wayne Viney & Clark Wolf (eds.) - 2005 - Lexington Books.
    In this thorough compendium, nineteen accomplished scholars explore, in some manner the values they find inherent in the world, their nature, and revelence through the thought of Frederick Ferré. These essays, informed by the insights of Ferré and coming from manifold perspectives—ethics, philosophy, theology, and environmental studies, advance an ambitious challenge to current intellectual and scholarly fashions.
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  42.  29
    Going from the ME to the WE: A Long Journey to Where You Are.David G. Blumenkrantz - 2017 - Anthropology of Consciousness 28 (2):193-205.
    What if individual psychology took another path than the one guided by the idea of the “Sturm und Drang” of adolescence? What if this path less-traveled led to community-oriented rites of passage that satisfied youth's deep craving for the ancestral wisdom of the Universe … and simultaneously affirmed that parents, too, would continue to grow and contribute as they transited mid-life? This article brings the reader down the path less-traveled to explore navigational aids for future travelers and provides an example (...)
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  43.  64
    Nature, Truth, and Value: Exploring the Thinking of Frederick Ferrz.George Allan, Merle Allshouse, Harley Chapman, John B. Cobb, John Compton, Donald A. Crosby, Paul T. Durbin, Barbara Meister Ferré, Frederick Ferré, Frank B. Golley, Joseph Grange, John Granrose, David Ray Griffin, David Keller, Eugene Thomas Long, Elisabethe Segars McRae, Leslie A. Muray, William L. Power, James F. Salmon, Hans Julius Schneider, Dr Kristin Shrader-Frechette, Udo E. Simonis, Donald Wayne Viney & Clark Wolf (eds.) - 2005 - Lexington Books.
    In this thorough compendium, nineteen accomplished scholars explore, in some manner the values they find inherent in the world, their nature, and revelence through the thought of Frederick FerrZ. These essays, informed by the insights of FerrZ and coming from manifold perspectives—ethics, philosophy, theology, and environmental studies, advance an ambitious challenge to current intellectual and scholarly fashions.
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  44. The Future Lasts a Long Time and The Facts, The Althusserian Legacy. [REVIEW]David Macey - 1994 - Radical Philosophy 67.
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  45.  20
    Prefrontal Cortex Activation During Motor Sequence Learning Under Interleaved and Repetitive Practice: A Two-Channel Near-Infrared Spectroscopy Study.Maarten A. Immink, Monique Pointon, David L. Wright & Frank E. Marino - 2021 - Frontiers in Human Neuroscience 15.
    Training under high interference conditions through interleaved practice results in performance suppression during training but enhances long-term performance relative to repetitive practice involving low interference. Previous neuroimaging work addressing this contextual interference effect of motor learning has relied heavily on the blood-oxygen-level-dependent response using functional magnetic resonance imaging methodology resulting in mixed reports of prefrontal cortex recruitment under IP and RP conditions. We sought to clarify these equivocal findings by imaging bilateral PFC recruitment using functional near-infrared spectroscopy while discrete (...)
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  46.  44
    Becoming a Xhosa Healer: Nomzi’s Story.Beauty N. Booi & David J. A. Edwards - 2014 - Indo-Pacific Journal of Phenomenology 14 (2):1-12.
    This paper presents the story of an isiXhosa traditional healer, Nomzi Hlathi, as told to the first author. Nomzi was asked about how she came to be an igqirha and the narrative focuses on those aspects of her life story that she understood as relevant to that developmental process. The material was obtained from a series of semi-structured interviews with Nomzi, with some collateral from her cousin, and synthesised into a chronological narrative presented in Nomzi’s own words. The aim of (...)
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  47.  44
    The Legal and Ethical Status of Children in Health Care in the UK.Rosario Baxter, Ann Long & David Sines - 1998 - Nursing Ethics 5 (3):189-199.
    Ethical issues about children’s rights in respect of matters concerning resource allocation or treatment opportunities are now a matter for public consumption and concern. Alongside this exists a long-frustrated desire by children’s nurses to promote children’s health. Long-held assumptions about the legal and moral status of children within the health care system in this country are now rightly scrutinized and challenged. Those of us who claim to represent children now possess an opportunity to exploit public attention for the (...)
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  48. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.David C. Whitcomb, Jessica LaRusch, Alyssa M. Krasinskas, Lambertus Klei, Jill P. Smith, Randall E. Brand, John P. Neoptolemos, Markus M. Lerch, Matt Tector, Bimaljit S. Sandhu, Nalini M. Guda, Lidiya Orlichenko, Samer Alkaade, Stephen T. Amann, Michelle A. Anderson, John Baillie, Peter A. Banks, Darwin Conwell, Gregory A. Coté, Peter B. Cotton, James DiSario, Lindsay A. Farrer, Chris E. Forsmark, Marianne Johnstone, Timothy B. Gardner, Andres Gelrud, William Greenhalf, Jonathan L. Haines, Douglas J. Hartman, Robert A. Hawes, Christopher Lawrence, Michele Lewis, Julia Mayerle, Richard Mayeux, Nadine M. Melhem, Mary E. Money, Thiruvengadam Muniraj, Georgios I. Papachristou, Margaret A. Pericak-Vance, Joseph Romagnuolo, Gerard D. Schellenberg, Stuart Sherman, Peter Simon, Vijay P. Singh, Adam Slivka, Donna Stolz, Robert Sutton, Frank Ulrich Weiss, C. Mel Wilcox, Narcis Octavian Zarnescu, Stephen R. Wisniewski, Michael R. O'Connell, Michelle L. Kienholz, Kathryn Roeder & M. Micha Barmada - unknown
    Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele (...)
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  49.  24
    Sonic Hedgehog as a mediator of long‐range signaling.John A. Goetz, Liza M. Suber, Xin Zeng & David J. Robbins - 2002 - Bioessays 24 (2):157-165.
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    Protocol for the development of a CONSORT extension for RCTs using cohorts and routinely collected health data.Brett D. Thombs, David Torgerson, Maureen Sauvé, David Erlinge, Eric I. Benchimol, Helena M. Verkooijen, Rudolf Uher, Lehana Thabane, Tjeerd P. van Staa, Kimberly A. Mc Cord, Marion K. Campbell, Philippe Ravaud, Isabelle Boutron, David Moher, Sinéad M. Langan, Merrick Zwarenstein, Chris Gale, Clare Relton, Ole Fröbert, Margaret Sampson, Lars G. Hemkens, Edmund Juszczak & Linda Kwakkenbos - 2018 - Research Integrity and Peer Review 3 (1).
    BackgroundRandomized controlled trials (RCTs) are often complex and expensive to perform. Less than one third achieve planned recruitment targets, follow-up can be labor-intensive, and many have limited real-world generalizability. Designs for RCTs conducted using cohorts and routinely collected health data, including registries, electronic health records, and administrative databases, have been proposed to address these challenges and are being rapidly adopted. These designs, however, are relatively recent innovations, and published RCT reports often do not describe important aspects of their methodology in (...)
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